PIAS3 (protein inhibitor of activated STAT, 3)

Down-Regulation of NFATc1 and Modulates Osteoclastogenesis by Protein Inhibitor of Activated STAT 3

Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).

Smad proteins play pivotal roles in mediating the transforming growth factor beta (TGF-beta) transcriptional responses. We show in this report that PIAS3, a member of the protein inhibitor of activated STAT (PIAS) family, activates TGF-beta/Smad transcriptional responses. PIAS3 interacts with Smad proteins, most strongly with Smad3. PIAS3 and Smad3 interact with each other at the endogenous pro...

Activated stat-3 in melanoma.

BACKGROUND Recent studies have demonstrated that the Src-Stat pathway may play an important role in melanoma. We examined the expression of phosphorylated Stat-3 (pStat-3), activated Stat-1 (pStat-1) and interferon alpha receptor subunit 1(IFNAR-1) in human melanocytic neoplasms. METHODS Compound nevi (6), dysplastic nevi (4), congenital nevi (2), primary melanoma (14), and sentinel lymph nod...

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.

Protein inhibitor of activated STAT3 (PIAS3) has been shown to regulate the activity of various transcription factors. In this study, we show that the overexpression of PIAS3 in bone marrow-derived monocyte/macrophage lineage cells attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclasto...

A novel role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the restriction of herpes

24 Small Ubiquitin like MOdifier (SUMO) is used by the intrinsic antiviral immune response to 25 restrict viral pathogens, such as Herpes Simplex Virus 1 (HSV-1). Despite characterization of 26 the host factors that rely on SUMOylation to exert their antiviral effects, the enzymes that 27 mediate these SUMOylation events remain to be defined. We show that unconjugated SUMO 28 levels are largely...